Abstract:

Objective To explore the application value of Shenqi Jiangtang granules combined with lira⁃ glutide for type 2 diabetic patients who do not respond to metformin therapy. Methods A total of 150 patients with type 2 diabetes who received treatment in our hospital from April 2017 to October 2019 were divided into three groups：A，B，and C，with 50 subjects in each group. All patients received metformin，group A was given liraglu⁃ tide，group B was given Shenqi Jiangtang granules，and group C was given Shenqi Jiangtang granules combined with liraglutide. The blood glucose levels，efficacy，visfatin，pancreatic islet function，TCM syndrome scores and adverse reactions of the three groups were compared before and after the treatment. Results After treatment，the blood glucose level of group C was significantly lower than that of group A and group B（P < 0.05）. The total effec⁃ tive rate of group A、B and C was 78%，82% and 96%，respectively. The total effective rate of group C was signifi⁃ cantly higher than that of group A and group B（P < 0.05）. The level of visfatin in group C was significantly lower than that in group A and group B（P < 0.05）. The HOMA⁃β of group C was significantly higher than that of group A and group B（P < 0.05）. The TCM syndrome score of group C was significantly lower than that of group A and group B（P < 0.05）. No serious adverse reactions were found in the three groups（P > 0.05）. Conclusion Shenqi Jiangtang granules combined with liraglutide could significantly improve the efficacy without increasing adverse drug reactions，and could be applied to type 2 diabetes patients who do not respond to metformin. 

Key words:

type 2 diabetes, liraglutide, Shenqi Jiangtang granules, visfatin, islet function